PC-026 · nootropic · dihexa
Dihexa
N-hexanoic-Tyr-Ile-(6) aminohexanoic amide
§ Overview
An oligopeptide derived from angiotensin IV that is reportedly 10 million times more potent than BDNF at promoting new neural connections. Dihexa was developed at Washington State University and has shown remarkable cognitive enhancement in animal studies, particularly for memory restoration.
§ Mechanism
Binds to hepatocyte growth factor (HGF) and its receptor c-Met, dramatically amplifying HGF/c-Met signaling in the brain. This promotes dendritic spine formation, synaptic connectivity, and neuronal repair. The mechanism is distinct from traditional nootropics.
§ Common Uses
- → Cognitive enhancement
- → Memory improvement
- → Neural repair
- → Alzheimer's research
§ Reported Side Effects
- · Unknown (no human trials)
- · Theoretical cancer risk (HGF/c-Met pathway)
- · Headache (anecdotal)
§ Research, Experiences & Trends
Mechanism of Action
Binds to hepatocyte growth factor (HGF) and its receptor c-Met, dramatically amplifying HGF/c-Met signaling in the brain. This promotes dendritic spine formation, synaptic connectivity, and neuronal repair. The mechanism is distinct from traditional nootropics.
Common Uses
Dosage & Pharmacology
Known Side Effects
- • Unknown (no human trials)
- • Theoretical cancer risk (HGF/c-Met pathway)
- • Headache (anecdotal)