PC-020 · antimicrobial · kpv
KPV
Lys-Pro-Val
Also: Alpha-MSH C-terminal tripeptide
Lys-Pro-Val
§ Overview
A naturally occurring tripeptide derived from the C-terminal end of alpha-MSH (alpha-melanocyte-stimulating hormone). KPV has potent anti-inflammatory properties and has shown promise in treating inflammatory bowel disease (IBD), skin conditions, and infections. It works without the tanning/sexual effects of full melanocortin peptides.
§ Mechanism
Enters cells and directly inhibits inflammatory signaling by blocking NF-κB nuclear translocation. Reduces pro-inflammatory cytokines (TNF-α, IL-6, IL-1β). Has direct antimicrobial properties against Staphylococcus aureus and Candida albicans.
§ Common Uses
- → Gut inflammation (IBD)
- → Skin conditions
- → Anti-inflammatory
- → Antimicrobial
- → Wound healing
§ Reported Side Effects
- · Generally well-tolerated
- · Mild GI upset (oral, rare)
§ Research, Experiences & Trends
Mechanism of Action
Enters cells and directly inhibits inflammatory signaling by blocking NF-κB nuclear translocation. Reduces pro-inflammatory cytokines (TNF-α, IL-6, IL-1β). Has direct antimicrobial properties against Staphylococcus aureus and Candida albicans.
Common Uses
Dosage & Pharmacology
Known Side Effects
- • Generally well-tolerated
- • Mild GI upset (oral, rare)