PC-010 · nootropic · dsip
DSIP
Delta Sleep-Inducing Peptide
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
§ Overview
A neuropeptide originally isolated from rabbit brain cerebral venous blood during induced sleep. DSIP modulates sleep architecture, stress responses, and pain perception. Despite its name, it doesn't directly induce sleep but rather normalises sleep patterns and improves sleep quality.
§ Mechanism
Modulates GABAergic and glutamatergic neurotransmission, affects hypothalamic-pituitary-adrenal axis to reduce cortisol, and influences serotonin and dopamine pathways. Promotes slow-wave (delta) sleep without sedation.
§ Common Uses
- → Sleep quality
- → Stress reduction
- → Pain management
- → Withdrawal support
- → Circadian rhythm regulation
§ Reported Side Effects
- · Mild headache
- · Transient hypotension
- · Morning grogginess (rare)
§ Research, Experiences & Trends
Mechanism of Action
Modulates GABAergic and glutamatergic neurotransmission, affects hypothalamic-pituitary-adrenal axis to reduce cortisol, and influences serotonin and dopamine pathways. Promotes slow-wave (delta) sleep without sedation.
Common Uses
Dosage & Pharmacology
Known Side Effects
- • Mild headache
- • Transient hypotension
- • Morning grogginess (rare)