PC-022 · longevity · mots-c
MOTS-c
Mitochondrial ORF of the 12S rRNA type-c
§ Overview
A mitochondrial-derived peptide (MDP) encoded by the mitochondrial genome. MOTS-c acts as a mitochondrial signal to the nucleus, regulating metabolic homeostasis and exercise biology. It's been called an 'exercise mimetic' for its ability to replicate some benefits of physical exercise.
§ Mechanism
Activates AMPK signaling pathway, the master metabolic regulator. Translocates to the nucleus under metabolic stress to regulate gene expression. Enhances glucose uptake independent of insulin, improves fatty acid oxidation, and protects against metabolic dysfunction.
§ Common Uses
- → Metabolic optimization
- → Exercise mimetic
- → Insulin sensitivity
- → Fat loss
- → Longevity
§ Reported Side Effects
- · Injection site irritation
- · Mild hypoglycemia (theoretical)
§ Research, Experiences & Trends
Mechanism of Action
Activates AMPK signaling pathway, the master metabolic regulator. Translocates to the nucleus under metabolic stress to regulate gene expression. Enhances glucose uptake independent of insulin, improves fatty acid oxidation, and protects against metabolic dysfunction.
Common Uses
Dosage & Pharmacology
Known Side Effects
- • Injection site irritation
- • Mild hypoglycemia (theoretical)