PC-024 · longevity · nad-plus
NAD+
Nicotinamide Adenine Dinucleotide
Also: NAD · Coenzyme I
§ Overview
While technically a coenzyme rather than a peptide, NAD+ is included here due to its centrality in the longevity/biohacking community. NAD+ levels decline ~50% between ages 40-60. It's essential for cellular energy production, DNA repair, and sirtuin activation. Supplemented via precursors (NMN, NR) or direct IV/subcutaneous NAD+.
§ Mechanism
Essential cofactor for redox reactions in mitochondrial energy production. Activates sirtuins (SIRT1-7) — the 'longevity genes' that regulate DNA repair, inflammation, and metabolism. Required substrate for PARP enzymes (DNA repair) and CD38 (immune signaling).
§ Common Uses
- → Anti-aging
- → Cellular energy
- → DNA repair support
- → Addiction recovery
- → Cognitive function
§ Reported Side Effects
- · Nausea
- · Chest tightness (IV)
- · Flushing
- · Cramping (IV)
- · Anxiety during IV infusion
§ Research, Experiences & Trends
Mechanism of Action
Essential cofactor for redox reactions in mitochondrial energy production. Activates sirtuins (SIRT1-7) — the 'longevity genes' that regulate DNA repair, inflammation, and metabolism. Required substrate for PARP enzymes (DNA repair) and CD38 (immune signaling).
Common Uses
Dosage & Pharmacology
Known Side Effects
- • Nausea
- • Chest tightness (IV)
- • Flushing
- • Cramping (IV)
- • Anxiety during IV infusion