PC-023 · longevity · ss-31
SS-31
Elamipretide
Also: Bendavia · MTP-131
D-Arg-Dmt-Lys-Phe-NH2
§ Overview
A mitochondria-targeted tetrapeptide that concentrates 1000-5000x in mitochondria. SS-31 stabilises cardiolipin, a critical phospholipid in the inner mitochondrial membrane, restoring electron transport chain function. Currently in clinical trials for heart failure and mitochondrial diseases.
§ Mechanism
Selectively binds to cardiolipin on the inner mitochondrial membrane, stabilising cytochrome c interactions and optimising electron transport chain efficiency. Reduces reactive oxygen species (ROS) production at the source rather than scavenging them after formation.
§ Common Uses
- → Mitochondrial support
- → Heart failure
- → Aging/cellular energy
- → Exercise recovery
- → Kidney protection
§ Reported Side Effects
- · Injection site reactions
- · Headache
- · Mild GI symptoms
§ Research, Experiences & Trends
Mechanism of Action
Selectively binds to cardiolipin on the inner mitochondrial membrane, stabilising cytochrome c interactions and optimising electron transport chain efficiency. Reduces reactive oxygen species (ROS) production at the source rather than scavenging them after formation.
Common Uses
Dosage & Pharmacology
Known Side Effects
- • Injection site reactions
- • Headache
- • Mild GI symptoms